These data indicated that PXN-AS1 was upregulated in human bone marrow of CML patients with Imatinib resistance and CML IR cell lines, implying that PXN-AS1 might serve as a crucial factor for GS-mediated BCR::ABL1-independent Imatinib resistance in CML cells. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.