In addition, lncRNA PXN-AS1 promoted BCR::ABL1-independent resistance to Imatinib in CML through the PXN-AS1/miR-635/GS/Gln/mTOR/Cyclin D-CDK4/6 complex signaling pathway. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.