One study found that PVT1/miR-619-5p/Pygo2 and PVT1/miR-619-5p/ATG14 regulatory axes could mediate gemcitabine resistance in pancreatic cancer cells by activating Wnt/β-catenin signaling pathway and autophagy signaling pathway respectively [32]. The gene discussed is PYGO2; the disease is familial pancreatic carcinoma.