PYCR1, a well-characterized tumor promoting factor, attracted our attention for the following reasons: (1) PYCR1 was frequently dysregulated in malignant tumors; (2) PYCR1 might be interact with BHLHE41; (3) PYCR1 might be participated in regulating PI3K/AKT signaling. This evidence concerns the gene BHLHE41 and cancer.