AFF3 is also GWAS-/MTAG-associated with diabetes (type 1, type 2, diabetic nephropathy, and HDL cholesterol), addictions (smoking initiation, alcohol consumption, cannabis dependence, television watching), autoimmunity (lupus, celiac disease, rheumatoid and juvenile idiopathic arthritis), sexual development and dimorphism (age at menarche, endometriosis, mammographic density, male baldness, biological sex), blood measurements (e.g., hematocrit, hemoglobin measurement), eye diseases (e.g., astigmatism, intraocular pressure, corneal measurements), and insomnia [56]. Here, AFF3 is linked to juvenile idiopathic arthritis.