Mitochondrial calcium uniporter regulator 1 (MCUR1) (OR 2.836; 95% CI 1.263–6.367; P = 0.016) and RAS-related protein Rap-2a (RAP2A) (OR 4.909; 95% CI 1.849–13.039; P = 0.001) were up-regulated in T2D-PBMCs and demonstrated risk influence on T2D. Here, RAP2A is linked to type 2 diabetes mellitus.