However, nuclear factor IX (NFIX) (OR 0.420; 95% CI 0.207–0.850; P = 0.016), pannexin 1 (PANX1) (OR 0.839; 95% CI 0.744–0.947; P = 0.004) and with no lysine-1 (WNK1) (OR 0.265; 95% CI 0.102–0.689; P = 0.006) were up-regulated in T2D-PBMCs and showed protective influence on T2D (Fig. 4B-C). This evidence concerns the gene PANX1 and type 2 diabetes mellitus.