We found that iSGLT2 promoted lysosome accumulation and autophagy cell death via LC3B activation in CRC cells and along with ER stress induction and upregulation of the molecular players related to autophagy triggered by ER stress, namely ER-phagy, i.e., PERK, CHOP and ATF6 [45, 67, 68]. The gene discussed is DDIT3; the disease is colorectal carcinoma.