To investigate the role of glucose transporter SGLT2 in the metabolic pathways and tumorigenesis of CRC cells, firstly the SGLT2 mRNA and protein levels were determined in normal colon CCD 841 CoN and four CRC cell lines, HCT 116, HT-29, SW480 and LoVo (Fig. 1). The gene discussed is SLC5A2; the disease is colorectal carcinoma.