DPP4 and type 2 diabetes mellitus: Treatment with the iSGLT2 dapagliflozin reduced DPP4 serum levels in patients with type 2 diabetes and non-alcoholic fatty liver disease [85], while the DPP4 inhibitor sitagliptin ameliorated the ischemia/reperfusion-induced injury in cardiomyocytes by mediating SIRT3 upregulation and autophagy [49].