Remarkably, blockage the transsulfuration pathway by inhibition of cystathionine β-synthase and cystathionine γ-lyase with aminooxyacetic acid (AOAA) led to increased pancreatic edema and increased inflammatory infiltrate in TRP14 KO mice with pancreatitis when compared to TRP14 KO mice with pancreatitis but without AOAA treatment (Fig. 9E–G), which was confirmed by immunohistochemistry using the anti-CD11b/Integrin alpha antibody as a marker for neutrophil infiltration (Appendix Fig. S4). The gene discussed is ITGAM; the disease is pancreatitis.