GCLC and alkaline phosphatase measurement: Evaluating the complete proteome in the pancreatic tissue samples from the different animal groups, TRP14 KO mice showed a major alteration of the global proteome, with a large number of proteins showing significantly altered levels both under basal conditions and in AP, also confirming the upregulation of Nrf2 targets in TRP14 KO mice with AP, including Gclc and glutathione S-transferase P1 (Gstp, Appendix Figs. S5–S9).