The overexpression of Hmga2 induced a myeloproliferative phenotype in a transgenic mouse (Ikeda et al, 2011), and drove the development of myeloproliferative neoplasms induced by the JAK2V617F mutation or Tet2 deletion in mouse models (Shimizu et al, 2016; Sashida et al, 2016; Bai et al, 2021). Here, HMGA2 is linked to myeloproliferative disorder.