EPAS1 and hereditary clear cell renal cell carcinoma: For example, on chr2p for renal cell carcinoma, four genes centromeric of the driver EPAS1 (ref. 40) (C2orf73, ARHGAP25, VAX2 and LRRTM4) satisfy these criteria, as do two genes on chr18q for B-lymphoblastic leukemia and lymphoma centromeric to the driver BCL2 (ref. 41) (ELOA2 and GRP) and three genes on chr2p for neuroblastoma genes centromeric to the driver SOX11 (ref. 42) (KCNF1, NTSR2 and FAM166C) (Supplementary Table 7).