ADH1B and alcohol dependence: Early GWAS of Alcohol Dependence and measures of problematic drinking collectively identified more than 10 risk variants that mapped to several risk genes, most notably the alcohol dehydrogenase genes ADH1B (Alcohol Dehydrogenase 1B [class I], Beta Polypeptide) and ADH1C (Alcohol Dehydrogenase 1 C [class I], Gamma Polypeptide) [8].