Interestingly, several transcriptome-wide significant and colocalized genes outside genome-wide significant GWAS loci point to biologically relevant pathways related to neurodevelopment and neurodegeneration (PICALM, a known Alzheimer disease gene [47, 87–89], CAMSAP2, AGTPBP1, SETD1A, EPRS, PADI2 and PSAP). This evidence concerns the gene PADI2 and early-onset autosomal dominant Alzheimer disease.