Older age (F(2,239) = 40.3, p < 0.001), greater amyloid burden (F(2,170) = 82.3, p < 0.001), and greater tau burden (Braak I/II: F(2,141) = 47.5, p < 0.001; Braak III/IV: F(2,141) = 55.9, p-value < 0.001; Braak V/VI: F(2,141) = 27.2, p < 0.001) were associated with more advanced AD-related diagnostic group from Cognitively-Stable to MCI-DS and AD dementia, highlighting the strong age-dependency of disease-related factors in this population (Table 1). Here, MAPT is linked to Alzheimer disease.