Single-point mutations in STING are drivers of STING-associated vasculopathy with onset in infancy (SAVI disease), a condition characterized by skin lesions, rashes, and interstitial lung disease8 and thus antagonizing STING, e.g., through downregulation of STING expression, may have a high potential therapeutic value in the field of immunology9. Here, STING1 is linked to vascular disorder.