However, the contribution of specific 5-HT2AR-initiated pathways to SCZ-like symptoms (i.e. positive, negative and cognitive deficits) via the engagement of various subtypes of Gα protein subunits, i.e. Gαq or Gαi proteins, and β-arrestins3,9–12 has remained largely elusive. This evidence concerns the gene GNAQ and Cognitive impairment.