We first investigated the results for psoriasis and asthma, where GenoBoost ranked second (pseudo-R2 = 0.0308) after snpboost27 (pseudo-R2 = 0.0310), given the known role of the MHC locus in both traits and the difference between the two traits in the polygenicity (Supplementary Fig. 8). The gene discussed is HLA-C; the disease is asthma.