Third, it is well documented that intratumoral cDC1 numbers are associated with the improved prognosis and responses to cancer immunotherapy.9,47 CCL4, CCL5 and XCL1, regulate migration of cDC1.6,9,19 We also uncovered that BCL9 and β-catenin drive Wnt signaling to promote XCR1+ cDC1 migration via XCL1, thereby offering a novel mechanism for targeting Wnt/β-catenin signaling to promote cDC1 tumor infiltration. This evidence concerns the gene XCR1 and cancer.