Given the multiple effects of targeted IL-22-ScFv in improving hyperglycemia, hepatic inflammation, steatosis, and fibrosis, we generated pancreatic beta-cell specific IL-22ra1 knockout mice (Ins2-Cre x IL-22ra1fl/fl) hereafter referred to as IL-22ra1βcell−/−, to dissect the tissue-specific effects of mIL-22-ScFv. Here, IL22 is linked to Hyperglycemia.