Dex triggered a strong upregulation of phospho-PLCγ2 in B-ALL cell lines, which was impaired in CRISPR-Cxcr4 and siCXCR4 cells as well as after exposure to CXCR4 antagonists (Fig. 6n, o and Supplementary Fig. 17i–l). This evidence concerns the gene PLCG2 and acute lymphoblastic leukemia.