Subsequently, we measured Dex-induced Ca2+ signaling in these transfected cells and found that Dex did not induce increases in the cytosolic Ca2+ in CRISPR-Cxcr4 cells, demonstrating that CXCR4 controls Dex-induced Ca2+ signaling in B-ALL cells (Fig. 6l, m and Supplementary Fig. 16y, z). Here, CXCR4 is linked to precursor B-cell acute lymphoblastic leukemia.