HSPG2 and acute lymphoblastic leukemia: GSEA analysis of our RNA-seq revealed an enrichment of the GR pathway and the cellular response to Dex stimulus genes in U73122-treated cells (Fig. 5l and Supplementary Fig. 11c–e) and an increase in GR expression after treatment with manoalide (Supplementary Fig. 11f, g), further indicating that the sensitivity of B-ALL cells to GC is dependent on PLC function.