HSPG2 and precursor B-cell acute lymphoblastic leukemia: IP3R-mediated ER Ca2+ release following carbachol (Cch) (Fig. 1h, j and Supplementary Fig. 2d) or ATP stimulation (Fig. 1i, k and Supplementary Fig. 2e) was also significantly reduced in presence of PLC inhibitors, suggesting that in B-ALL, PLC-γ2 is constitutively active and functional.