As shown in Fig. 6p–s and Supplementary Fig. 17q, r, Dex stimulation triggered a strong downregulation of CXCR4 surface expression in four B-ALL cell lines, i.e., (Nalm-6, Reh, RS4;11 and HAL-01), consistently with previous reports demonstrating that CXCR4 internalization occurs 2–5 min after activation53,55. The gene discussed is CXCR4; the disease is precursor B-cell acute lymphoblastic leukemia.