On a larger scale, our results hint at a role of tau in HD pathology, which has, in recent years, been increasingly investigated (Blum et al., 2015; Gratuze et al., 2015; L’Episcopo et al., 2016; Liu et al., 2019; Alpaugh et al., 2022; Mees et al., 2022a; Petrozziello et al., 2023). This evidence concerns the gene MAPT and Huntington disease.