LY86 and myotonic dystrophy type 1: As reported, many mRNAs exhibit an increased mis-splicing under pathological conditions (53), while the RNA helicase DDX6 can relieve this mis-splicing event, for example, overexpression of DDX6 can reduce the mis-splicing of Ppp2r5c and IR2 in the patients of myotonic dystrophy type 1 (MD1) (54).