Although the LOX region of LOXL2Δ13 is shortened and its deamination activity is partially reduced, LOXL2Δ13 is more strongly transforming in esophageal squamous cell carcinoma cells, compared to LOXL2WT, indicating that the cancer-promoting function of LOXL2Δ13 does not depend on LOX activity (6). This evidence concerns the gene LOX and cancer.