SRSF9 and cardiac hypertrophy: Based on these findings, the present study proposes a novel mechanistic paradigm of cardiac hypertrophy under pressure overload: TAC → Mettl1↑ → SRSF9 mRNA m7G↑ → SRSF9↑ → NFATc4↑ → hypertrophic genes↑ → cardiac hypertrophy/remodeling↑ → cardiac function↓.