To elucidate the mechanism by which Mettl1 drives cardiac hypertrophy, we employed RNA‐seq combined with m7G methylated RNA sequencing (m7G‐seq) for whole transcriptome profiling and m7G sites mapping in Mettl1‐overexpressing mouse myocardium and NMCMs, respectively. Here, METTL1 is linked to cardiac hypertrophy.