A recent study identified trans‐acting transcription factor 1 (SP1) and Yin Yang‐1 (YY1) as potential transcriptional factors of Mettl1, considering their implication in cardiac hypertrophy.[18, 19, 20, 21] To investigate this, we constructed siRNAs for YY1 and SP1 and examined the alteration of Mettl1 expression after knocking down YY1 or SP1, respectively. Here, SP1 is linked to cardiac hypertrophy.