HPSE and Sepsis: Based on the strategy of substrate analogs inhibition of the enzyme, several oligosaccharide inhibitors targeting HPA have been designed in the previous research, including SST001,[35] M402,[36] and PI88.[37] These inhibitor drugs have entered clinical research for the treatment of tumors in which HPA is overexpressed, which provides great confidence in our research to develop oligosaccharide inhibitors for sepsis.