Notably, Kwak andco-workers found that EFEMP1 knockdown attenuated hypoxia-inducedbreast cancer growth and metastasis.52 Thisprotein has also been related to neovascularization in macular degeneration.53 These researchers also identified an upregulationof VEGF by EFEMP1 and observed increased tube formation and proliferationof HUVEC overexpressing EFEMP1. This evidence concerns the gene VEGFA and cancer.