demonstrated that hypoxia‐inducible factor‐1α (HIF‐1α) directly binds to the HRE‐3 in the FTL promoter region to inhibit FTL expression and modulate the AKT/GSK3β/β‐catenin signalling pathway, ultimately suppressing the EMT process and reducing gliomas cell migration and invasion. The gene discussed is HIF1A; the disease is central nervous system cancer.