AKT1 and Alzheimer disease: Furthermore, the enrichment analysis of key genes, which serve as the molecular links between Alzheimer’s and metabolic syndrome, revealed the focal adhesion pathway, PI3K-Akt signaling pathway, ECM-receptor interaction (ECM-receptor interactions can impair cell signaling pathways, promote neuroinflammation, and contribute to the progression of AD pathology), and the HIF-1 signaling pathway as the notable pathways.