In neuroblastoma, Thakur et al found that OX40 expression was strikingly low in tumour tissue from a group of 100 paediatric cancers, including neuroblastoma, Ewing’s sarcoma, medulloblastoma, osteosarcoma and rhabdomyosarcoma [49]. The gene discussed is TNFRSF4; the disease is rhabdomyosarcoma.