While these prognostic trends conflict with the trends observed in our model, several studies have also found that elevated expression of TNFRSF4 and its protein counterpart OX40 as favourable in cancers, including colorectal cancer (CRC) [39,40], cutaneous malignant melanoma [41] and endometrial carcinoma (EC) [42]. Here, TNFRSF4 is linked to colorectal carcinoma.