RUNX1 and hereditary elliptocytosis: This is in favour of the idea that the polarity status of HE cells has a direct incidence on the cell type that will arise, with a stronger chance to evolve as an EHT pol+ cell if apical and basal domains are already determined (which is the case for HE cells upon dt-Runx1 expression) and a lesser chance if these domains are not established and the pool of intracellular vacuoles/pseudo-vacuoles is reduced (see the hypothetical model Figure 2B).