BAIAP2L2 is an epithelial-specific BAR domain protein closely related to cell migration,42 the overexpression of which may promote GC carcinogenesis via regulating AKT/mTOR and Wnt3a/β-catenin pathways.43 Our study confirmed BAIAP2L2 overexpression in advanced gastric lesions and further upregulation in GC tissues. Here, AKT1 is linked to gastric cancer.