Additionally, there is substantial evidence thatmitophagy defects are another major contributor to hepatocellularinjury in the progression of NAFLD.25,26 PTEN-inducedputative kinase1 (PINK1) and Parkin have been proposed to be key regulatorsof mitophagy.27 However, whether the inhibitionof FFAs-induced hepatic cell damage by Hst is associated with PINK1/Parkin-drivenmitophagy remained unresolved. This evidence concerns the gene PRKN and metabolic dysfunction-associated steatotic liver disease.