ALKBH5 is generally downregulated in HCC, and decreased demethylation of LINC01468 increased its expression, driving NAFLD-HCC progression through CUL4A-linked degradation of SHIP2 and subsequent activation of the PI3K/AKT/mTOR signaling pathway (Wang et al., 2022b). The gene discussed is CUL4A; the disease is hepatocellular carcinoma.