Has_circ_0008583 sponges miR-1301-3p to promote METTL3 expression (Wang et al., 2022a), and circMAP2K4 sponges miR-139-5p to promote YTHDF1 expression (Chi et al., 2021), both of which further HCC progression. The gene discussed is METTL3; the disease is hepatocellular carcinoma.