Similarly, METTL3 upregulates double homeobox A pseudogene 8 (DUXAP8), which, by sponging miR-584-5p, promotes MAPK1 expression and activates the MAPK/ERK pathway, causing chemoresistance in HCC (Liu et al., 2021b). This evidence concerns the gene METTL3 and hepatocellular carcinoma.