Risk factors for the development of DM-related SIH according to the univariate analysis are as follows: male gender (OR 4.97, 95% CI 1.66–14.92, p = 0.003) and ILD presence (OR 9.71, 95% CI 2.99–31.47, p < 0.001); anti-MDA5 positivity (OR 16.0, 95% CI 1.60-159.3, p = 0.06); anti-Ro52 positivity (OR 11.6, 95% CI 2.93–46.34, p < 0.001); heparin use (OR 4.42, 95% CI 2.68–7.24, p < 0.001); and steroid dose (OR 1.03, 95% CI 1.00-1.05, p = 0.005). Here, TRIM21 is linked to interstitial lung disease.