The positive association of ANGPTL8 with the occurrence of NAFLD has also been demonstrated with respects to progression across the disease spectrum, since patients with moderate to severe NAFLD appear to have higher ANGPTL8 levels compared to patients with mild NAFLD, posing this ANGPTL as a potential marker for disease monitoring in different stages [123, 126]. Here, ANGPTL8 is linked to metabolic dysfunction-associated steatotic liver disease.