Aquaporins (Aqp) are water channels involved in the fluid transportacross cell membranes and also present in many important barriersof the eye.84 Strong evidence shows thatAqp3 and Aqp5 are expressed in the CE.85 Aquaporins have also been investigated as potential targets in thetreatment of age-related eye disorders such as glaucoma.86 The high expression in the CE (R: 218.2 ± 41.8 and P: 440.6 ± 152.9 fmol/cm2) supports the potential of using the aquaporins as therapytargets. The gene discussed is AQP5; the disease is glaucoma.