He started showing significant hemolysis with hemoglobinuria, 5607 u/L LDH, 78,000/mm3 thrombocytopenia, with schistocytes in the peripheral blood, normal clot test assays, negative direct Coombs, reduced renal function and worsening of liver enzymes (total bilirubin at 4.71 mg/dL, with direct, 3.47 mg/dL, and indirect, 1.24 mg/dL; aspartate transaminase [AST] 5383 u/L and alanine transaminase [ALT] 1794 u/L). The gene discussed is GPT; the disease is Thrombocytopenia.