ZMPSTE24 and restrictive dermopathy: While HGPS and MADA are linked to mutations in the LMNA gene, MADB and restrictive dermopathy are associated with a mutation in ZMPSTE24, a gene that encodes a zinc metalloproteinase necessary for the correct processing of prelamin A to mature lamin A.5,10 NGPS, on the other hand, is due to a mutation in the BANF1 gene, which plays key roles in gene expression, nuclear assembly and chromatin organization.11 The genetic analysis performed in the patient revealed the mutation c.1579C>T (p.R527C) in exon 9 of the LMNA gene, leading to the diagnosis of MADA.