RUNX2 and diabetes mellitus: Our results are in agreement with those from previous experiments in murine models of Diabetes or MS, in which we found that altered hydrocarbon metabolism caused a decrease in the in vitro osteogenic potential of BMPC (lower RUNX2 expression, type 1 collagen production, bone alkaline phosphatase activity, and extracellular mineralization) as well as in vivo alterations in bone trabecular microarchitecture (mild in MS rats, greater in diabetic rats) 12,13,.20