In addition to the above-described functions, some studies have reported that the SOCS1-p53 axis is also involved in the regulation of ferroptosis, because SOCS1 promotes p53 phosphorylation, which acts as a transcriptional repressor to inhibit SLC7A11 expression, thereby improving the sensitivity of tumor cells to ferroptosis[89–90]. The gene discussed is TP53; the disease is neoplasm.