In the univariable analysis, the factors associated with a long-term decrease in the FIB-4 index greater than one included RBV usage, cirrhosis, baseline FIB-4 stage, total bilirubin levels, direct bilirubin levels, cholinesterase levels, ALP levels, GGT levels, total protein levels, albumin levels, TBA levels, T-Chol levels, HDL-C levels, LDL-C levels, and ApoB levels (Supplementary Table 2, available online). This evidence concerns the gene APOB and Cirrhosis.