In the univariable analysis, several factors were found to be associated with a short-term decrease in the FIB-4 index greater than one, including RBV usage, cirrhosis, baseline FIB-4 stage, total bilirubin levels, direct bilirubin levels, cholinesterase levels, ALP levels, GGT levels, albumin levels, HGB levels, AFP levels, TBA levels, T-Chol levels, LDL-C levels, and ApoB levels (Supplementary Table 1, available online). The gene discussed is AFP; the disease is Cirrhosis.