Connections between the VTA and NAc are intricately related to the VTA–hypothalamus circuit, a network which is modulated by leptin and supports reward feeding behaviours.136 Moreover, this connections plays a key role in chronic emotional stress and anxiety-related behaviours.137 In humans, the fibre tract interconnecting the VTA with the NAc has been associated with impulsivity.138 VTA efferents to the PFC are modulated by chronic stress, which induces different structural and functional sex-dependent changes.139. Here, LEP is linked to Anxiety.