In obese mouse models, the CRIg+ macrophage population has been found significantly reduced, resulting in a strong increase of bMV translocation to AT.50 The subsequent enrichment of gut-derived bMVs in AT, as detected by a marked increase in bacterial DNA, is accompanied by local inflammation and aggravated insulin resistance.50 In human subjects, however, a clinically significant influence of bMV capture by CRIg+ macrophages, on parameters such as AT inflammation has not been demonstrated yet. The gene discussed is VSIG4; the disease is Insulin resistance.