So far, using genome-wide association studies (GWAS), research studies have revealed that several genetic susceptibility loci play a vital role in RA, such as the human leukocyte antigen D-related B1 gene (HLA-DRB1) and protein tyrosine phosphatase non-receptor type 22 (PTPN22) (Tanaka, 2020). The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.