Aldose reductase activity, as well as both phases of glucose-induced insulin release by the perfused rat pancreas preparation, are potently inhibited by GLA and its equivalents.27 Directly, the presence of glucose causes the release of insulin from pancreatic β-cells when SUA, SA, and AZA are present.3,28,29 AZA therapy significantly increased the amount of hepatic glycogen in type 2 diabetes patients and mice with high-fat diet-induced diabetes. The gene discussed is INS; the disease is diabetes mellitus.