POMC and Cushing syndrome due to macronodular adrenal hyperplasia: It could be assumed that the discrepancy in the sex dysmorphism of cardiometabolic and bone alterations between patients with ACTH-dependent Cushing syndrome and patients with MACS could be due to the different lengths of exposure to cortisol excess, and also to the different interactions of the HPA axis with the gonadal hormones, in these different settings.