In the presentstudy, either in vivo or IPK studies showed that a singleinjection of RVV and venom fraction of either PLA2 or MP can increasethe concentration of IL-10 and IL-5, in both plasma and urine at 10-30 minutes.It would suggest that both anti-inflammatory cytokines for IL-5 and IL-10 play arole in various kidney diseases by activating an anti-inflammatory response,immunoregulation, and relieving kidney tissue fibrosis. This evidence concerns the gene IL10 and kidney disorder.