ABO and Alzheimer disease: In vivo and in vitro evidence indicates that inhibiting Drp1-induced mitochondrial fission can protect against synaptic injury in AD model mice and N2a cells (Baek et al., 2017; Reddy et al., 2017); heterozygous Drp1 knockout mice exhibit significantly reduced levels of AβO (Manczak et al., 2012).