TBK1 and Alzheimer disease: The expression of mitophagy-related proteins such as BCL2-like 13 (Bcl2L13), PINK1, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L), phosphorylated UNC-51-like kinase 1 (p-ULK1), phosphorylated TANK-binding kinase 1 (p-TBK1), and FUN14 domain-containing protein 1 (FUNDC1) is downregulated in the brains of AD patients and their derived induced pluripotent stem cells, indicating defects in the mitophagy pathway in AD (Fang et al., 2019).