The expression of mitophagy-related proteins such as BCL2-like 13 (Bcl2L13), PINK1, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L), phosphorylated UNC-51-like kinase 1 (p-ULK1), phosphorylated TANK-binding kinase 1 (p-TBK1), and FUN14 domain-containing protein 1 (FUNDC1) is downregulated in the brains of AD patients and their derived induced pluripotent stem cells, indicating defects in the mitophagy pathway in AD (Fang et al., 2019). This evidence concerns the gene FUNDC1 and Alzheimer disease.