PROS1 and dementia: ZnT3 knockout was shown to affect hippocampal neuron plasticity in mice, and is also one of the important factors in dementia (McAllister and Dyck, 2017), which is consistent with findings showing the mice lacking ZnT3 exhibit reduced activation of key synaptic plasticity proteins (e.g., presynaptic MAPK signaling), leading to the synaptic impairment and memory deficits (Sindreu et al., 2011).