Magnesium acts as an allosteric activator for adenylate cyclase, Na/K-ATPase, and phospholipase C. Magnesium downregulates IL-1 alpha, IL-4, IL-6, IL-1 beta, Il-10, IL-12, TNF-alpha and several chemokines involved in hypertension, numerous immune-inflammatory pathways, and in adverse pregnancies. Here, TNF is linked to hypertensive disorder.