Copper (I) ions can produce reactive oxygen species (ROS) (Figure 3), catalyze the Haber–Weiss reaction, and induce insulin resistance by ROS leading to altered glucose homeostasis.15,16,21,22 Lysyl oxidase (LOX), a copper-containing enzyme, is involved in oxidizing lysine and hydroxylysine residues present in precursors of elastin and collagen, also enabling crosslinking in the amniotic membrane. The gene discussed is ELN; the disease is Insulin resistance.