TTR and preeclampsia: (Figure 3).19,37 Since preeclampsia is a proteinopathy disorder with impaired autophagy, protein aggregates (Aβ, TTR, P-tau231, and α-syn) are generated by impaired autophagy in the placenta or kidneys.90 In PE, the lipid peroxidation product, malondialdehyde, and altered amyloid-b production generate protein aggregates, toxic amyloid-b42 species, and their specific components α-syn, TTR, P-tau231, and Aβ.90