Given the high frequency of DDX43 hypomethylation in hematologic malignancies due to DNMT3A mutations [22], nevertheless, the pattern of DDX43 methylation has not been well studied in AML; in this study, we aim to evaluate the relation between DNMT3A R882H mutations and DDX43 methylation status in Iranian patients with AML. This evidence concerns the gene DDX43 and acute myeloid leukemia.