DNMT3A and acute myeloid leukemia: Our results demonstrated that 10.6% of the patients showed R882H mutation, and this mutation was significantly associated with decreased methylation in DDX43 gene (P < 0.05), suggesting the possible role of DNMT3A function in promoter methylation and transcriptional inactivation of DDX43. Our result may shed a light on the mechanism of action of DNMT3A mutation R882H, which is a prognostic factor for AML patients.