Therefore, following our line of argument, TLR4 activation by Pg-LPS increases PD1/PDL1 expression in T-cells and GC cells, leading to simultaneous T-cell exhaustion by PD1 and an increase in PDL1, which allows gastric tumor progression, culminating in a decrease in patient survival which evidences this fact (Figure 2). Here, CD274 is linked to gastric neoplasm.