In patients without clinical symptoms or a history of liver disease, with normal liver tumor markers levels such as AFP but significantly elevated NSE levels, the presence of multiple intrahepatic masses with peripheral cyst/necrosis and similar rim arterial phase hyper-enhancement along with peripheral ‘washout’ in venous portal and delayed phases on CT or MR imaging should raise suspicion for hepatic NENs. Here, ENO2 is linked to cyst.